pentobarbital will lessen the level or influence of nisoldipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will minimize the extent or impact of meloxicam by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Unfamiliar.pentobarbital increases toxicity of ifosfamide